创伤后应激障碍的生物标志物研究进展

张泽瀚; 费晓炜; 吕伟豪; 蔡敏; 庄茁; 王化宁; 费舟

doi:10.11883/bzycj-2024-0222

创伤后应激障碍的生物标志物研究进展

doi: 10.11883/bzycj-2024-0222

张泽瀚^1,,
费晓炜¹,
吕伟豪¹,
蔡敏¹,
庄茁²,
王化宁¹,
费舟^1, ,

1.
空军军医大学西京医院，陕西西安 710032
2.
清华大学航天航空学院，北京 100084

基金项目: 国家重点研究发展计划（2020-JCJQ-ZD-254-04）；空军军医大学基础加强计划（2023JSYX04）

详细信息

作者简介:
张泽瀚（1996－　），男，硕士，医师，17601365622@163.com

通讯作者:
费　舟（1961－　），男，博士，主任医师，feizhou@fmmu.edu.cn

中图分类号: O383
计量
- 文章访问数: 20
- HTML全文浏览量: 4
- PDF下载量: 1
- 被引次数: 0
出版历程
- 收稿日期: 2024-07-04
- 修回日期: 2024-10-13
- 网络出版日期: 2024-10-18

Research progress on biomarkers of post-traumatic stress disorder

1.
Xijing Hospital, Air Force Medical University, Xiʼan 710032, Shaanxi, China
2.
School of Aerospace Engineering, Tsinghua University, Beijing100084, China

摘要

摘要: 创伤后应激障碍（post-traumatic stress disorder，PTSD）源于个体经历创伤性事件后所产生的精神健康障碍，常为爆炸或冲击等外部因素所触发，特别在军事战争中其患病率异常显著，对患者及社会造成极大危害。目前对PTSD的诊断仍缺乏客观标准，对其进行筛查和定性诊断存在困难。本文总结了最新的PTSD相关遗传易感性生物标志物、神经影像学发现的大脑结构及功能改变相关的生物标志物、外周自主神经系统功能变化以及特异性外周体液生物标志物的研究进展，并探讨了这些生物标志物在临床中的潜在应用。生物标志物研究可以为理解PTSD的神经生物学机制提供关键线索，为患者提供更有效的筛查、诊断和疾病监测手段。PTSD的生物标志物的开发已经历了选择目的标志物、进行实验内部验证确定检验效能和外部验证确定标志物的可用性等阶段，目前正处于验证临床效用阶段，需要多中心、大样本量数据对候选标志物进行检测并确定其成本效益。此外，基于生物标志物与临床生理学及人口统计学风险因素的综合应用显示出潜在优势，在验证其相对于问卷调查的优越性后，基于体液蛋白组学检测所构建的多蛋白指标联合诊断模型将为PTSD的诊断提供坚实依据。
- 创伤后应激障碍 /
- 生物标志物 /
- 蛋白质组学 /
- 遗传易感性 /
- 核磁共振
Abstract: Post-traumatic stress disorder (PTSD) is a complex mental health condition that can arise after a person experiences or witnesses a traumatic event. These events can range from combat situations in military conflicts to natural disasters or personal assaults. The impact of PTSD on individuals and society as a whole is profound, often leading to significant emotional distress and functional impairment. Despite its prevalence, accurately diagnosing PTSD remains a challenge due to the lack of standardized diagnostic criteria. Recent advancements in PTSD research have focused on identifying biomarkers that can aid in the diagnosis and monitoring of the disorder. These biomarkers include genetic susceptibility markers, changes in brain structure and function detected through neuroimaging techniques, alterations in the autonomic nervous system, and specific fluid markers that may indicate biological changes associated with PTSD. By studying these biomarkers, researchers hope to gain a better understanding of the underlying neurobiological mechanisms of PTSD, ultimately leading to more effective screening and treatment strategies. The development of PTSD biomarkers involves a rigorous process of validation, from initial target selection to internal and external validation experiments. Currently, researchers are working towards confirming the clinical utility of these biomarkers through large-scale studies involving multiple research centers and diverse patient populations. By integrating biomarkers with clinical data and demographic risk factors, there is potential to create a comprehensive diagnostic model for PTSD that surpasses traditional questionnaire-based assessments. In the future, a multi-protein diagnostic model based on fluid proteomics profiling could revolutionize the way PTSD is diagnosed and managed. This approach holds promise for providing clinicians with a more reliable and objective tool for identifying and treating individuals with PTSD, ultimately improving outcomes for patients and reducing the burden of this debilitating condition on society.
- post-traumatic stress disorder /
- biomarkers /
- proteomics /
- genetic susceptibility /
- magnetic resonance imaging

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