According to the existing blasting vibration live data, the different-frequency-band energy distribution of the blasting vibration signals was attained by the wavelet analysis technology. Based on the characteristics of dynamic response from the controlled structures by blasting vibration, a multi-factor blasting vibration safety criterion was proposed, also called the response energy criterion, in which taking the total influence of the intensity, frequency and duration of vibration and the characteristics (natural frequency and damping ratio) of dynamic response from the controlled structures themselves into account. The feasibility of the proposed criterion was validated by the engineering examples. Results show that this response energy criterion can describe accurately the effect degree of blasting vibration on the controlled structures, and that it can reflect the essence of blasting vibration damage to the structures more comprehensively than the actual velocity-frequency safety criterion.