创伤后应激障碍的生物标志物研究进展

张泽瀚 费晓炜 吕伟豪 蔡敏 庄茁 王化宁 费舟

张泽瀚, 费晓炜, 吕伟豪, 蔡敏, 庄茁, 王化宁, 费舟. 创伤后应激障碍的生物标志物研究进展[J]. 爆炸与冲击. doi: 10.11883/bzycj-2024-0222
引用本文: 张泽瀚, 费晓炜, 吕伟豪, 蔡敏, 庄茁, 王化宁, 费舟. 创伤后应激障碍的生物标志物研究进展[J]. 爆炸与冲击. doi: 10.11883/bzycj-2024-0222
ZHANG Zehan, FEI Xiaowei, LV Weihao, CAI Min, ZHUANG Zhuo, WANG Huaning, FEI Zhou. Research progress on biomarkers of post-traumatic stress disorder[J]. Explosion And Shock Waves. doi: 10.11883/bzycj-2024-0222
Citation: ZHANG Zehan, FEI Xiaowei, LV Weihao, CAI Min, ZHUANG Zhuo, WANG Huaning, FEI Zhou. Research progress on biomarkers of post-traumatic stress disorder[J]. Explosion And Shock Waves. doi: 10.11883/bzycj-2024-0222

创伤后应激障碍的生物标志物研究进展

doi: 10.11883/bzycj-2024-0222
基金项目: 国家重点研究发展计划(2020-JCJQ-ZD-254-04);空军军医大学基础加强计划(2023JSYX04)
详细信息
    作者简介:

    张泽瀚(1996- ),男,硕士,医师,17601365622@163.com

    通讯作者:

    费 舟(1961- ),男,博士,主任医师,feizhou@fmmu.edu.cn

  • 中图分类号: O383

Research progress on biomarkers of post-traumatic stress disorder

  • 摘要: 创伤后应激障碍(post-traumatic stress disorder,PTSD)源于个体经历创伤性事件后所产生的精神健康障碍,常为爆炸或冲击等外部因素所触发,特别在军事战争中其患病率异常显著,对患者及社会造成极大危害。目前对PTSD的诊断仍缺乏客观标准,对其进行筛查和定性诊断存在困难。本文总结了最新的PTSD相关遗传易感性生物标志物、神经影像学发现的大脑结构及功能改变相关的生物标志物、外周自主神经系统功能变化以及特异性外周体液生物标志物的研究进展,并探讨了这些生物标志物在临床中的潜在应用。生物标志物研究可以为理解PTSD的神经生物学机制提供关键线索,为患者提供更有效的筛查、诊断和疾病监测手段。PTSD的生物标志物的开发已经历了选择目的标志物、进行实验内部验证确定检验效能和外部验证确定标志物的可用性等阶段,目前正处于验证临床效用阶段,需要多中心、大样本量数据对候选标志物进行检测并确定其成本效益。此外,基于生物标志物与临床生理学及人口统计学风险因素的综合应用显示出潜在优势,在验证其相对于问卷调查的优越性后,基于体液蛋白组学检测所构建的多蛋白指标联合诊断模型将为PTSD的诊断提供坚实依据。
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  • 收稿日期:  2024-07-04
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