Abstract: The flexible support plate frame structure is an important component of the protective structure of large ships. To achieve rapid evaluation and design optimization of the protective effectiveness of flexible support plate structures under underwater explosions, this paper first establishes a method for evaluating the protective effectiveness of flexible support plate structures under underwater explosions based on high confidence simulation calculations and conducts experimental verification; Using a validated high confidence simulation calculation method combined with the optimal Latin hypercube in the sample space of key component parameters to obtain sample operating condition data. Using radial basis function neural network (RBF) model to construct a proxy model for quickly evaluating the protective effectiveness of flexible support plate structures.