Research progress on biomarkers of post-traumatic stress disorder

ZHANG Zehan; FEI Xiaowei; LV Weihao; CAI Min; ZHUANG Zhuo; WANG Huaning; FEI Zhou

doi:10.11883/bzycj-2024-0222

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ZHANG Zehan, FEI Xiaowei, LV Weihao, CAI Min, ZHUANG Zhuo, WANG Huaning, FEI Zhou. Research progress on biomarkers of post-traumatic stress disorder[J]. Explosion And Shock Waves. doi: 10.11883/bzycj-2024-0222

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ZHANG Zehan, FEI Xiaowei, LV Weihao, CAI Min, ZHUANG Zhuo, WANG Huaning, FEI Zhou. Research progress on biomarkers of post-traumatic stress disorder[J]. Explosion And Shock Waves. doi: 10.11883/bzycj-2024-0222

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Research progress on biomarkers of post-traumatic stress disorder

doi: 10.11883/bzycj-2024-0222

1.
Xijing Hospital, Air Force Medical University, Xiʼan 710032, Shaanxi, China
2.
School of Aerospace Engineering, Tsinghua University, Beijing100084, China

Received Date: 2024-07-04
Rev Recd Date: 2024-10-13

Available Online: 2024-10-18

Abstract

Abstract

Post-traumatic stress disorder (PTSD) is a complex mental health condition that can arise after a person experiences or witnesses a traumatic event. These events can range from combat situations in military conflicts to natural disasters or personal assaults. The impact of PTSD on individuals and society as a whole is profound, often leading to significant emotional distress and functional impairment. Despite its prevalence, accurately diagnosing PTSD remains a challenge due to the lack of standardized diagnostic criteria. Recent advancements in PTSD research have focused on identifying biomarkers that can aid in the diagnosis and monitoring of the disorder. These biomarkers include genetic susceptibility markers, changes in brain structure and function detected through neuroimaging techniques, alterations in the autonomic nervous system, and specific fluid markers that may indicate biological changes associated with PTSD. By studying these biomarkers, researchers hope to gain a better understanding of the underlying neurobiological mechanisms of PTSD, ultimately leading to more effective screening and treatment strategies. The development of PTSD biomarkers involves a rigorous process of validation, from initial target selection to internal and external validation experiments. Currently, researchers are working towards confirming the clinical utility of these biomarkers through large-scale studies involving multiple research centers and diverse patient populations. By integrating biomarkers with clinical data and demographic risk factors, there is potential to create a comprehensive diagnostic model for PTSD that surpasses traditional questionnaire-based assessments. In the future, a multi-protein diagnostic model based on fluid proteomics profiling could revolutionize the way PTSD is diagnosed and managed. This approach holds promise for providing clinicians with a more reliable and objective tool for identifying and treating individuals with PTSD, ultimately improving outcomes for patients and reducing the burden of this debilitating condition on society.
- post-traumatic stress disorder,
- biomarkers,
- proteomics,
- genetic susceptibility,
- magnetic resonance imaging

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References(83)

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