Abstract: To investigate the penetration resistance of metal honeycomb tube-constrained concrete structures under hypervelocity impact, penetration experiments were conducted using a two-stage light gas gun with projectile velocities near 1500 m/s. The Material Point Method (MPM) was employed to simulate the penetration process and validate the reasonableness of target and projectile parameters. This method was further used to analyze the effects of honeycomb tube parameters, including wall thickness, height, diameter, and material, on the penetration resistance of the target structure. Numerical simulations showed that MPM can accurately simulate high-velocity penetration processes, with simulation results deviating from experimental data by less than 10%. Through orthogonal analysis, the factors influencing penetration depth were ranked in descending order as follows: characteristic tube depth, characteristic inner diameter, characteristic wall thickness, and material. For the cratering effect, the primary influencing factors were identified as characteristic wall thickness, characteristic tube depth, material, and characteristic inner diameter. For the projectiles tested in this study, optimization results indicated the following: A combination of 4 mm wall thickness, 150 mm height, 30 mm incircle diameter, and tungsten alloy demonstrated the best penetration resistance, reducing penetration depth by 25.1% compared to plain concrete. A combination of 4 mm wall thickness, 150 mm height, 90 mm incircle diameter, and aluminum exhibited superior resistance to the cratering effect, decreasing crater radius by 28.7% compared to plain concrete. Multi-objective optimization analysis determined the optimal overall configuration to be: 4 mm wall thickness, 150 mm height, 30 mm incircle diameter, and aluminum.