Abstract: In order to study the blast performance of ultra-high performance concrete (UHPC) panels under intermedium-to-far-field explosion loading, a combined experimental and numerical simulation approach was adopted. This study specifically utilized explosion tests to evaluate the dynamic response of the panels, followed by residual load capacity tests to assess their post-blast and residual strength. Deterministic finite element models and equivalent Single Degree of Freedom (SDOF) models were established to simulate and analyze the mid-span peak deflection of the panels under different scaled distances. Establish a random finite element model using Gaussian auto-correlation random fields to examine the influence of spatial uncertainty in material property distribution. The results indicate that, UHPC panels maintain structural integrity under intermedium-to-far-field explosion, exhibiting a typical flexural damage mode; damage on the back-blast surface was concentrated in the mid-span region; the residual load capacity of the panel at a scaled distance of 1.0 even exceeded that of the unblasted specimen, demonstrating excellent blast resistance. The deterministic finite element model accurately predicted the blast response of the UHPC panel. The SDOF method showed high accuracy in predicting mid-span peak deflection but tended to overestimate it under minor damage conditions. The random finite element model, by incorporating Gaussian auto-correlated random fields, accounted for the uncertainty in mechanical properties of the material and demonstrated superior simulation results. Increasing the compressive strength of UHPC helps reduce mid-span peak deflection and structural damage. Furthermore, when the auto-correlation length of the random field was within the range of 10 mm to 20 mm, the damage characteristics predicted by the model were highly consistent with the actual observations. This study verifies the excellent blast resistance of UHPC under intermedium-to-far-range explosions, demonstrates the high fidelity and effectiveness of the random finite element model, and reveals the significant influence of material variability on the blast resistance assessment of UHPC structures.